UPTRAVI® (selexipag) Patient Resources

The following resources are designed to help you as you start treatment with UPTRAVI. You will also find common questions and answers about Actelion Pathways® and UPTRAVI.

Learn more about UPTRAVI

More information and downloads are available at Uptravi.com.

UPTRAVI Patient Brochure

A brochure that provides education about PAH and treatment with UPTRAVI.


UPTRAVI Prescribing Information

Help to Get You Started Patient Pamphlet

An outline of the support and services available once you have been prescribed UPTRAVI.

Dose Adjustment Phase Guide

A guide that highlights important steps and information about titration with UPTRAVI.


UPTRAVI Prescribing Information

Remember, your healthcare team should always be your first point of contact when you have questions about your health and treatment.

Support from our Nurse Counselors*

Patients who have enrolled with Actelion Pathways can speak with a Nurse Counselor* by calling
1-855-999-4724, Mon-Fri, 8 AM-8 PM ET. Nurse Counselors* are available to provide ongoing support and education to patients taking UPTRAVI.

*Nurse Counselors do not provide nursing services, treatment, or medical advice.

Frequently Asked Questions (FAQs)

Actelion Pathways is a program that provides you with support and services, including benefits verification.

Actelion provides a wide range of support and services through Actelion Pathways. If you choose to enroll, your Actelion Pathways Case Manager will call you to:

  • Help answer your questions about filling your prescription
  • Coordinate with your healthcare provider, insurance company, and specialty pharmacy to help find out if you have coverage for your medicine
  • Inform you of financial assistance programs based on your eligibility

The assistance of Actelion Pathways and Case Managers is available at no cost to patients taking UPTRAVI.

Enroll today. Call an Actelion Pathways Case Manager at 1-866-ACTELION (1-866-228-3546), Mon-Fri, 8 AM-8 PM ET.

Support in Spanish and other language services are available.

Your Actelion Pathways Case Manager may be able to help. Call 1-866-ACTELION (1-866-228-3546),
Mon-Fri, 8 AM-8 PM ET to speak with a Case Manager.

Support in Spanish and other language services are available.

To learn about the basic steps of getting an Actelion medicine,
download and review Steps to Getting Your Medicine.

A specialty pharmacy is a pharmacy that can ship certain medicines directly to your home. Actelion medicines are available by mail from a specialty pharmacy.

Learn about Working With a Specialty Pharmacy.

A specialty pharmacy will ship UPTRAVI to your home and may offer additional support services.

Either CVS Specialty or Accredo will call you to discuss financial responsibilities and shipment information.

You or your healthcare provider may have chosen additional support services such as an in-home nurse visit. Your specialty pharmacy will help you to schedule this.

Calls may come from a number you do not recognize. If you miss the call, try to call back as soon as possible to make sure your UPTRAVI shipment is not delayed.

Your insurance provider will need to gather information about your condition and your treatment before covering UPTRAVI. Sometimes, all their questions are answered at the time of prescription, but they may also need more information from your healthcare team, including:

  • Diagnostic test results, such as the numbers from your right heart catheterization (RHC)
  • Additional test results, including acute vasoreactivity testing or 6-minute walk distance (6MWD)
  • Details on past treatments you and your healthcare team have tried
  • Information missing from your prescription forms

You may receive additional optional support services, such as an in-home nurse visit before starting UPTRAVI and specialty pharmacy clinician calls during dose changes.

There are several programs that can help you pay for UPTRAVI. For information on these programs, contact an Actelion Pathways Case Manager at 1-866-ACTELION (1-866-228-3546), Mon-Fri, 8 AM-8 PM ET.

Commercially insured

If you receive insurance through your employer or purchase it privately, you may be eligible for the following program:

Actelion Oral PAH Therapy Co-pay Program*

A savings program that lets eligible patients pay $5 per prescription fill per product. Contact an Actelion Pathways Case Manager for more information.

Government insured

If you receive your medication through Medicare or other government-funded plans, you may be eligible for the following:

Independent foundations

There may be support available from independent third-party patient support foundations. An Actelion Pathways Case Manager can provide general information about resources.

Uninsured or underinsured

If you are uninsured or you have insurance but are unable to afford the out-of-pocket costs, you may be eligible for the following programs:

Patient Assistance Program (PAP)

A yearly program that helps eligible patients receive medicine at no cost. Contact an Actelion Pathways Case Manager to learn more and to ensure the PAP program is the best option for you before applying.

Bridge Program (temporary patient assistance program)

Offers up to 60 days of drug at no cost to eligible patients waiting for a coverage determination.

*Applies to patients who have provided consent to services offered by Actelion Pathways. The Actelion Oral PAH Therapy Co-pay Program is only available for residents of the US and Puerto Rico who are 18 or older and have commercial health insurance with co-pay/co-insurance exceeding $5 per prescription fill per product. Patients ineligible for the Actelion Oral PAH Therapy Co-pay Program include those enrolled in Medicare, Medicaid, VA/DoD (Tricare), the Indian Health Service, or any other federal- or state-funded healthcare program, or where prohibited by law. The Actelion Oral PAH Therapy Co-pay Program is not prescription drug coverage or insurance. Actelion reserves the right to terminate or modify this program at any time or without notice. Other terms and conditions apply.

Find out more in Finding Support and Financial Assistance and by speaking with a Case Manager.

There are independent organizations that can provide you with additional support and information:

The Pulmonary Hypertension Association is dedicated to increasing awareness and advocacy by providing information about PAH to both physicians and patients.

The Scleroderma Foundation offers a site for scleroderma patients, caregivers, and family members—dedicated to support, education, and research.

see more

What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information about UPTRAVI?

Who should not take UPTRAVI?

  • Do not take UPTRAVI if you take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects

What should I tell my doctor before taking UPTRAVI?

Tell your doctor if you:

  • Have liver problems
  • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
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What is UPTRAVI?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information about UPTRAVI?

Who should not take UPTRAVI?

  • Do not take UPTRAVI if you take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects

What should I tell my doctor before taking UPTRAVI?

Tell your doctor if you:

  • Have liver problems
  • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
  • Are pregnant or plan to become pregnant. It is not known if UPTRAVI will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI passes into your breast milk. You and your doctor should decide if you will take UPTRAVI or breastfeed. You should not do both
  • Have any other medical conditions
  • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements

What are the possible side effects of UPTRAVI?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Keep UPTRAVI and all other medicines away from children.

What other medicines might interact with UPTRAVI?

  • UPTRAVI and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor

How should I take UPTRAVI?

  • Take UPTRAVI exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI twice a day. Taking UPTRAVI with food may help you tolerate UPTRAVI better
  • Swallow UPTRAVI tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI
  • UPTRAVI is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg

Please see full Prescribing Information and Patient Product Information.

What is UPTRAVI?

+

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children.


IMPORTANT SAFETY INFORMATION

+

What is the most important information about UPTRAVI?

Who should not take UPTRAVI?

  • Do not take UPTRAVI if you take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects

What should I tell my doctor before taking UPTRAVI?

Tell your doctor if you:

  • Have liver problems
  • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
  • Are pregnant or plan to become pregnant. It is not known if UPTRAVI will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI passes into your breast milk. You and your doctor should decide if you will take UPTRAVI or breastfeed. You should not do both
  • Have any other medical conditions
  • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements

What are the possible side effects of UPTRAVI?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Keep UPTRAVI and all other medicines away from children.

What other medicines might interact with UPTRAVI?

  • UPTRAVI and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor

How should I take UPTRAVI?

  • Take UPTRAVI exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI twice a day. Taking UPTRAVI with food may help you tolerate UPTRAVI better
  • Swallow UPTRAVI tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI
  • UPTRAVI is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg

Please see full Prescribing Information and Patient Product Information.